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Table 1 Antimicrobial susceptibilities of B. vietnamiensis after serial exposure to antibiotics or hydrogen peroxide

From: Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis

Isolatea

MIC (μg/ml)b

AMK

GEN

KAN

TOB

AZM

MEM

CAZ

SXT

CIP

Clinical CF

         

 C8395 (3/11/1998, Bv1)

2

4

2

2

32

1

4

2/10

1

 D0774 (25/7/2003, Bv1)

>128

128

128

128

>2048

128

128

64/320

>32

 D0072 (15/03/2002, Bv3)

2

4

1

2

32

0.5

2

2/10

1

 D2910 (31/03/2008, Bv3)

128

32

64

32

>32

2

4

1/5

16

In vitro exposed

         

 C8395TE (TOB)

>128

>128

128

>128

64

1

4

4/20

4

 C8395AE (AZM)

32

16

16

16

2048

2

16

8/40

4

 C8395ME (MEM)

16

8

8

8

32

16

64

4/20

16

 C8395CE (CAZ)

8

8

4

4

32

8

16

2/10

16

 C8395SE (SXT)

8

8

2

2

32

0.5

4

>64/320

8

 C8395PE (peroxide)

32

64

32

32

32

4

16

4/20

4

 C8395PC (control)

8

8

4

8

32

1

4

1/5

1

 D0072TE (TOB)

32

32

16

16

>32

1

2

2/10

1

  1. aPatient identification numbers and bacterial isolation dates are noted in brackets. Abbreviations: TE, TOB exposed; AE, AZM exposed; ME, MEM exposed; CE, CAZ exposed; SE, SXT exposed; PE, hydrogen peroxide exposed; PC, passage control.
  2. bAminoglycoside and azithromycin MICs for C8395 and D0774, and tobramycin and azithromycin MICs for D0072, D2910, C8395TE, and D0072TE were previously published to some extent [13] and are shown here for comparison. MICs represent susceptibility after 3 passages on antibiotic-free media. Abbreviations: AMK, amikacin; GEN, gentamicin; KAN, kanamycin; TOB, tobramycin; AZM, azithromycin; MEM, meropenem; CAZ, ceftazidime; SXT, co-trimoxazole; CIP, ciprofloxacin.