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Table 1 Antimicrobial susceptibilities of B. vietnamiensis after serial exposure to antibiotics or hydrogen peroxide

From: Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis

Isolatea MIC (μg/ml)b
AMK GEN KAN TOB AZM MEM CAZ SXT CIP
Clinical CF          
 C8395 (3/11/1998, Bv1) 2 4 2 2 32 1 4 2/10 1
 D0774 (25/7/2003, Bv1) >128 128 128 128 >2048 128 128 64/320 >32
 D0072 (15/03/2002, Bv3) 2 4 1 2 32 0.5 2 2/10 1
 D2910 (31/03/2008, Bv3) 128 32 64 32 >32 2 4 1/5 16
In vitro exposed          
 C8395TE (TOB) >128 >128 128 >128 64 1 4 4/20 4
 C8395AE (AZM) 32 16 16 16 2048 2 16 8/40 4
 C8395ME (MEM) 16 8 8 8 32 16 64 4/20 16
 C8395CE (CAZ) 8 8 4 4 32 8 16 2/10 16
 C8395SE (SXT) 8 8 2 2 32 0.5 4 >64/320 8
 C8395PE (peroxide) 32 64 32 32 32 4 16 4/20 4
 C8395PC (control) 8 8 4 8 32 1 4 1/5 1
 D0072TE (TOB) 32 32 16 16 >32 1 2 2/10 1
  1. aPatient identification numbers and bacterial isolation dates are noted in brackets. Abbreviations: TE, TOB exposed; AE, AZM exposed; ME, MEM exposed; CE, CAZ exposed; SE, SXT exposed; PE, hydrogen peroxide exposed; PC, passage control.
  2. bAminoglycoside and azithromycin MICs for C8395 and D0774, and tobramycin and azithromycin MICs for D0072, D2910, C8395TE, and D0072TE were previously published to some extent [13] and are shown here for comparison. MICs represent susceptibility after 3 passages on antibiotic-free media. Abbreviations: AMK, amikacin; GEN, gentamicin; KAN, kanamycin; TOB, tobramycin; AZM, azithromycin; MEM, meropenem; CAZ, ceftazidime; SXT, co-trimoxazole; CIP, ciprofloxacin.