Skip to main content

Advertisement

Table 1 Risk factors for prolonged empirical antifungal treatment at ICU admission

From: Factors predicting prolonged empirical antifungal treatment in critically ill patients

Patient characteristics Prolonged empirical antifungal treatment p value
  Yes n = 77 No n = 76  
Age, years, mean ± SD 55 ± 14 60 ± 15 0.429
Male 42 (54) 49 (64) 0.277
SAPS II 54 (35, 71) 52 (37, 73) 0.518
LOD score 7 (4,10) 7.5 (4,11) 0.423
Location before ICU admission    0.963
  Other wards 60 (78) 58 (76)  
  Other ICUs 7 (9) 7 (9)  
  Home 10 (13) 11 (14)  
Recent hospitalization 34 (44) 22 (28) 0.058
Category of admission    0.500
  Medical 58 (75) 51 (67)  
  Surgical 18 (23) 23 (30)  
  Trauma 1 (1) 2 (2)  
Comorbidities    
  Diabetes 14 (18) 19 (25) 0.305
  Chronic heart failure 15 (19) 9 (12) 0.192
  COPD 15 (19) 16 (21) 0.809
  Cirrhosis 4 (5) 4 (5) >0.999
  Chronic dialysis 6 (7) 5 (6) 0.771
  Immunosuppression    
  Neutropenia 14 (18) 7 (9) 0.111
  Chemotherapy 22 (28) 8 (10) 0.005*
  Corticosteroids 21 (27.3) 9 (12) 0.017*
McCabe score    0.137
  Non fatal disease 24 (31) 34 (44)  
  Ultimately fatal disease 23 (29) 14 (18)  
  Rapidly fatal disease 30 (38) 28 (36)  
Causes for ICU admission**    
  Septic shock 42 (54) 36 (47) 0.374
  Acute exacerbation of COPD 21 (27) 14 (18) 0.192
  ARDS 13 (16) 20 (26) 0.156
  CAP 11 (14) 14 (18) 0.489
  HAP 24 (31) 12 (15) 0.024*
  Congestive heart failure 5 (6) 2 (2) 0.442
  Poisoning 2 (2) 8 (10) 0.056
  Neurologic failure 2 (2) 6 (7) 0.167
Infection on admission 72 (93) 58 (76) 0.002*
Prior antibiotic treatment 45 (58) 33 (43) 0.063
Prior antifungal treatment 25 (32.5) 10 (13) 0.004*
  1. *OR (95% CI) 3.3 (1.3-8.1), 2.7 (1.1-6.4), 2.4 (1.1-5.2), 4.4 (1.5-12.7), 3.1 (1.4-7.1); respectively.
  2. **Several patients had more than one cause for ICU admission.
  3. Data are n (%), or median (25th, 75th IQR), unless otherwise specified.
  4. SAPS, simplified acute physiology score; LOD, logistic organ dysfunction; ICU, intensive care unit; COPD, chronic obstructive pulmonary disease; ARDS, acute respiratory distress syndrome; CAP, community acquired pneumonia; HAP, hospital acquired pneumonia.