Table 1 Risk factors for prolonged empirical antifungal treatment at ICU admission
From: Factors predicting prolonged empirical antifungal treatment in critically ill patients
Patient characteristics | Prolonged empirical antifungal treatment | p value | |
|---|---|---|---|
Yes n = 77 | No n = 76 | ||
Age, years, mean ± SD | 55 ± 14 | 60 ± 15 | 0.429 |
Male | 42 (54) | 49 (64) | 0.277 |
SAPS II | 54 (35, 71) | 52 (37, 73) | 0.518 |
LOD score | 7 (4,10) | 7.5 (4,11) | 0.423 |
Location before ICU admission | 0.963 | ||
Other wards | 60 (78) | 58 (76) | |
Other ICUs | 7 (9) | 7 (9) | |
Home | 10 (13) | 11 (14) | |
Recent hospitalization | 34 (44) | 22 (28) | 0.058 |
Category of admission | 0.500 | ||
Medical | 58 (75) | 51 (67) | |
Surgical | 18 (23) | 23 (30) | |
Trauma | 1 (1) | 2 (2) | |
Comorbidities | |||
Diabetes | 14 (18) | 19 (25) | 0.305 |
Chronic heart failure | 15 (19) | 9 (12) | 0.192 |
COPD | 15 (19) | 16 (21) | 0.809 |
Cirrhosis | 4 (5) | 4 (5) | >0.999 |
Chronic dialysis | 6 (7) | 5 (6) | 0.771 |
Immunosuppression | |||
Neutropenia | 14 (18) | 7 (9) | 0.111 |
Chemotherapy | 22 (28) | 8 (10) | 0.005* |
Corticosteroids | 21 (27.3) | 9 (12) | 0.017* |
McCabe score | 0.137 | ||
Non fatal disease | 24 (31) | 34 (44) | |
Ultimately fatal disease | 23 (29) | 14 (18) | |
Rapidly fatal disease | 30 (38) | 28 (36) | |
Causes for ICU admission** | |||
Septic shock | 42 (54) | 36 (47) | 0.374 |
Acute exacerbation of COPD | 21 (27) | 14 (18) | 0.192 |
ARDS | 13 (16) | 20 (26) | 0.156 |
CAP | 11 (14) | 14 (18) | 0.489 |
HAP | 24 (31) | 12 (15) | 0.024* |
Congestive heart failure | 5 (6) | 2 (2) | 0.442 |
Poisoning | 2 (2) | 8 (10) | 0.056 |
Neurologic failure | 2 (2) | 6 (7) | 0.167 |
Infection on admission | 72 (93) | 58 (76) | 0.002* |
Prior antibiotic treatment | 45 (58) | 33 (43) | 0.063 |
Prior antifungal treatment | 25 (32.5) | 10 (13) | 0.004* |