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Table 1 Antibiotic resistance profile of S. flexneri 1c isolates from Egypt and Pakistan using both disk diffusion and E-test methods

From: Genetic characterization of antimicrobial resistance of Shigella flexneri 1c isolates from patients in Egypt and Pakistan

Antibiotics

AM1

C

TE

SXT

CET

CIP

CRO

FEB

CAZ

CTX

Ā 

S2

I

R

S

I

R

S

I

R

S

I

R

S

I

R

S

I

R

S

I

R

S

I

R

S

I

R

S

I

R

CLSI MIC3 breakpoints Ī¼g/mL

ā‰¤8

16

ā‰„32

ā‰¤ 8

16

ā‰„ 32

ā‰¤4

8

ā‰„16

ā‰¤2/38

Ā 

ā‰„4/76

ā‰¤8

16

ā‰„32

ā‰¤1

2

ā‰„4

ā‰¤1

2

ā‰„4

ā‰¤8

16

ā‰„32

ā‰¤4

8

ā‰„16

ā‰¤1

2

ā‰„4

EP4 isolates (nā€‰=ā€‰10) (1990ā€“1994)

0

0

10 (100)7

0

0

10 (100)

0

0

10 (100)

6 (60)

2 (20)

2 (20)

0

2 (20)

8 (80)

10 (100)

0

0

ND8

Ā Ā 

ND

Ā Ā 

ND

Ā Ā 

ND

Ā Ā 

EP isolates (nā€‰=ā€‰17) (2000ā€“2004)

1 (6)

0

16 (94)

16 (94)

0

1 (6)

2 (12)

0

15 (88)

2 (12)

0

15 (88)

1 (6)

14 (82)

2 (12)

17 (100)

0

0

17 (100)

0

0

17 (100)

0

0

17 (100)

0

0

17 (100)

0

0

NEP5 isolates (nā€‰=ā€‰19) (2001ā€“2003)

0

0

19 (100)

16 (84)

0

3 (16)

0

0

19 (100)

2 (11)

0

17 (89)

1 (5)

12 (63)

6 (32)

19 (100)

0

0

19 (100)

0

0

19 (100)

0

0

19 (100)

0

0

19 (100)

0

0

PP6 isolates (nā€‰=ā€‰23) (2002ā€“2003)

1 (4)

Ā 

22 (96)

4 (17)

Ā 

19 (83)

2 (9)

Ā 

21 (91)

1 (4)

Ā 

22 (96)

6 (26)

17 (74)

0

10 (100)

0

0

23 (100)

0

0

23 (100)

0

0

23 (100)

0

0

23 (100)

0

0

  1. 1AM Ampicillin, C Chloramphenicol, TE Tetracycline, SXT Trimethoprim sulfamethoxazole, CET Cephalothin, CIP Ciprofloxacin, CRO Ceftriaxone, FEB Cefepime, CAZ Ceftazidime, CTX Cefotaxime.
  2. 2S, I and R Susceptible, Intermediate and Resistant.
  3. 3MIC Minimum inhibitory concentrations.
  4. 4EP Egyptian pediatric isolates (<5Ā years).
  5. 5NEP Non-pediatric Egyptian isolates (9ā€“19Ā years).
  6. 6PP Pakistan pediatric isolates (<5Ā years).
  7. 7 () % of isolates.
  8. 8ND Not done.