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Table 4 Genotype distribution of 60 erythromycin-resistant S. pneumoniae (ERSP) isolates from middle ear fluids: association with serotypes and co-resistance to penicillin

From: Microbiological characterization of Streptococcus pneumoniae and non-typeable Haemophilus influenzae isolates as primary causes of acute otitis media in Bulgarian children before the introduction of conjugate vaccines

Resistance genotype

Total no. (%) (n = 128)

Co-resistance to penicillin1 n (%)

Serotypes of ERSP (n)

  

R

I

S

 

 erm(B)

34 (56.7)

6 (17.6)

25 (73.5)

3 (8.8)

6B (16); 19A (9); 19 F (6); 14, 23 F, 23A (1) each

 mef(E)

15 (25.0)

3 (20.0)

11 (73.3)

1 (6.7)

14 (10); 19 F (3); 6B, 15B (1) each

 erm(B) + mef(E)

9 (15.0)

6 (66.7)

3 (33.3)

-

19 F (7); 19A (2)

L42

2 (3.3)

2 (100.0)

-

-

19A (2)

Total no. (%) of ERSP

60 (46.9)

17 (28.3)

39 (65.0)

4 (6.7)

-

  1. R-resistant; I-intermediate; S-susceptible (Interpretation according to CLSI, 2010); 1The following breakpoints (μg/mL) for penicillin (oral penicillin V) were used: susceptible ≤ 0.06; intermediate ≥ 0.12 - 1.0; resistant ≥ 2. 2 Mutations in ribosomal protein L4 were determined as described elsewhere [21].
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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