Brain MRI of the patient. Axial T2-FLAIR imaging obtained soon after admission showed abnormal hyperintensities in the bilateral basal ganglia (arrows in A) without enhancement (B). After 7 weeks on anti-cryptococcal therapy, axial T2-FLAIR images showed partial resolution of the lesion (arrows in C). Twenty-five weeks after initiation of anti-retroviral therapy and while on fluconazole maintenance therapy, axial T2-FLAIR images showed abnormal hyperintensities in bilateral basal ganglia again (arrows in D) with irregular patchy enhancement (arrows in E). After 19 days on corticosteroids and intensified anti-cryptococcal therapy, T2-FLAIR images showed near complete resolution of brain lesions (F).