Table 1 Minimal inhibitory concentrations (MICs) of manumycin A, amphotericin B, itraconazole, and voriconazole against Aspergillus and Candida determined by standard broth microdilution method
Amphotericin B | Itroconazole | Voriconazole | Caspofungin | Manumycin A | |
|---|---|---|---|---|---|
(μg/ml) | (μg/ml) | (μg/ml) | (μg/ml) | (μM) | |
A. fumigatus-1 | 1 | 0.5 | 0.5 | 0.06 | 200 |
A. fumigatus-2 | 1 | 0.5 | 1 | 0.06 | 400 |
A. fumigatus-3 | 1 | 0.25 | 0.5 | 0.06 | 200 |
A. flavus-1 | 1 | 0.5 | 1 | 0.125 | 200 |
A. flavus-2 | 1 | 0.5 | 1 | 0.125 | 200 |
A. terreus-1 | 2 | 0.5 | 0.5 | 0.06 | 200 |
C. albicans-1 | 0.5 | 0.25 | 0.25 | 1 | 25 |
C. albicans-2 | 1 | 0.25 | 0.5 | 0.5 | 13 |
C. albicans-3 | 1 | 0.5 | 0.5 | 0.5 | 13 |
C. albicans-4 | 0.5 | 0.25 | 0.25 | 1 | 25 |
C. tropicalis-1 | 1 | 0.125 | 0.125 | 0.5 | 13 |
C. tropicalis-2 | 1 | 0.25 | 0.125 | 0.5 | 25 |
C. glabrata-1 | 1 | 0.5 | 0.25 | 1 | 25 |
C. glabrata-2 | 1 | 0.25 | 0.125 | 1 | 25 |
C. krusei-1 | 0.5 | 1 | 0.5 | 0.25 | 25 |
C. krusei-2 | 0.5 | 1 | 0.5 | 0.25 | 25 |
C. parapsilosis | 0.5 | 0.25 | 0.06 | 1 | 25 |