Table 1 Demographic and clinical characteristics of study patients
Age (month) [median (minimum-maximum)] | 36 (3–204) | |
Male gender [number (%)] | 22 (%62.9) | |
Weight (kg) [median (minimum-maximum)] | 12 (3–70) | |
Comorbidity [number (%)] | 30 (85.7%) | |
● Chronic neurological or neuromuscular disorders | 10 (28.6%) | |
● Congenital heart disease | 8 (2.9%) | |
● Inherited metabolic disorders | 5 (14.3%) | |
● Primary immune deficiency | 4 (11.4%) | |
● Malignancy | 1 (2.9%) | |
● Others | 2 (5.7%) | |
Immune deficiency [number (%)] | 9 (%25.7) | |
● Primary immune deficiency | 2 | |
● Immunosuppressive treatment | 7 | |
Cause of PICU admission | ||
● Respiratory failure | 21 (%60.0) | |
● Acute loss of consciousness, CNS infections or status epilepticus | 6 (%17.1) | |
● Post-operative follow-up or complications | 4 (%11.4) | |
● Sepsis or shock | 3 (%8.6) | |
● Poisoning | 1 (%2.9) | |
Length of stay in PICU before infection (day) [median (min-max)] | 30 (0–126) | |
Total length of stay in hospital before infection (day) [median (min-max)] | 39 (0–142) | |
Duration of mechanical ventilation (day) [median (min-max)] | 25 (0–108) | |
Medical devices (existed at the beginning of colistin treatment) | ||
● Endotracheal or tracheostomy tube | 41 (100%) | |
● Central venous or arterial catheter | 33 (80.5%) | |
● Foley catheter | 30(73.2%) | |
● Thorax tube | 2 (4.9%) | |
● External ventricular drainage catheter | 2 (4.9%) | |
● Peritoneal dialysis catheter | 1 (2.4%) | |
PRISM score at admission of PICU | 18.4 ± 9.2 | |
PELOD score at the start of colistin treatment | 16.2 ± 9.7 | |
Organ failure at the start of colistin treatment | ||
● Neurological | 30 (73.2%) | |
● Respiratory | 40 (97.6%) | |
● Cardiac | 12 (29.3%) | |
● Renal | 3 (7.3%) | |
● Hepatic | 2 (4.9%) | |
● Hematologic | None |