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Table 2 Results of adaptive resistant experiments of selected carbapenem-resistant Acinetobacter baumannii isolates

From: Hetero- and adaptive resistance to polymyxin B in OXA-23-producing carbapenem-resistant Acinetobacter baumannii isolates

Strain PFGE group MIC (mg/L) Polymyxin B MIC of subpopulations selected in PAP Highest concentration of polymyxin B where growth was observed (mg/L) MIC after 3 days daily passages in drug-free medium (mg/L) MIC after 60 days storage (mg/L)
2 A ≤ 0.125 2 64 32 NP
3 A 0.25 NA 64 16 NP
5 A 0.25 1 NG NA NA
6 A 1 1 64 16 NP
7 B ≤ 0.125 0.5 64 16 NP
8 B 0.25 1 64 16 NP
9 B ≤ 0.125 0.5 64 16 NP
10 C ≤ 0.125 1 64 32 ≤ 0.125
12 C ≤ 0.125 1 64 16 NP
14 D ≤ 0.125 1 NG NA NA
15 E 0.25 1 NG NA NA
16 F 0.5 2 NG NA NA
17 F ≤ 0.125 1 NG NA NA
18 G 0.25 1 64 ≥ 64 NP
19 H 0.25 1 NG NA NA
20 I 0.25 2 NG NA NA
22 J 0.25 1 64 16 0.25
23 K 0.25 NA NG NA NA
24 L ≤ 0.125 0.5 64 16 ≤ 0.125
26 M ≤ 0.125 1 64 ≥ 64 ≤ 0.125
27 N 0.5 2 NG NA NA
29 O ≤ 0.125 1 NG NA NA
  1. PAP population analysis profiles, NA not applicable, NG no growth, NP not performed.