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Table 1 Results of population analysis profile (PAP) of selected carbapenem-resistant Acinetobacter baumannii isolates

From: Hetero- and adaptive resistance to polymyxin B in OXA-23-producing carbapenem-resistant Acinetobacter baumannii isolates

Strain PFGE group MIC (mg/L) Highest concentration where growth occurred in population analysis (mg/L) Frequency of appearance of subpopulations (PAP) MIC after 4 days daily passages in drug-free medium (mg/L) MIC after 75 days storage (mg/L)
1 A ≤ 0.125 1 6.6 × 10-5 1 ≤ 0.125
2 A ≤ 0.125 2 6 × 10-5 2 ≤ 0.125
3 A 0.25 NG NA NA NA
4 A ≤ 0.125 1 1 × 10-7 1 NP
5 A 0.25 1 5 × 10-5 1 NP
6 A 0.25 1 1.5 × 10-6 1 NP
7 B ≤ 0.125 0.5 5 × 10-4 0.5 ≤ 0.125
8 B 0.25 1 2.5 × 10-7 1 0.25
9 B ≤ 0.125 0.5 1 × 10-6 0.5 NP
10 C ≤ 0.125 1 1.2 × 10-5 1 ≤ 0.125
11 C 1 1 NA 1 1
12 C ≤ 0.125 1 7.1 × 10-5 1 NP
13 D ≤ 0.125 1 1.3 × 10-6 1 NP
14 D ≤ 0.125 1 3.3 × 10-6 1 NP
15 E 0.25 1 1 × 10-6 1 NP
16 F 0.5 2 8.3 × 10-5 2 1
17 F ≤ 0.125 1 1 × 10-6 1 ≤ 0.125
18 G 0.25 1 7.5 × 10-5 1 0.25
19 H 0.25 1 3.3 × 10-4 1 0.25
20 I 0.25 2 3.3 × 10-5 2 1
21 I 0.5 1 3 × 10-6 1 1
22 J 0.25 1 1.4 × 10-4 1 0.25
23 K 0.25 NG NA NA NA
24 L ≤ 0.125 0.5 1.5 × 10-6 0.5 ≤ 0.125
25 L ≤ 0.125 1 4 × 10-4 1 NP
26 M ≤ 0.125 1 6.2 × 10-4 1 ≤ 0.125
27 N 0.5 2 6.6 × 10-5 2 1
28 N ≤ 0.125 0.5 1.5 × 10-5 0.5 NP
29 O ≤ 0.125 1 5 × 10-5 0.5 0.5
  1. PAPs population analysis profiles, NA not applicable, NG no growth, NP not performed.