Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin

Table 1 Minimum inhibitory concentrations (MIC; μg/mL) of different statins against standard bacteria

Statins	Rosuvastatin	Atorvastatin	Simvastatin
	MIC; μg/mL	MIC; μg/mL	MIC; μg/mL
E. coli ATTC 35218	104.17 ± 36.08	26.04 ± 9.02*	52.08 ± 18.04
P. aeruginosa ATTC 9027	166.67 ± 72.16	83.33 ± 36.08	166.67 ± 72.16
MSSA ATTC 25213	208.33 ± 72.16	41.67 ± 18.04*	26.04 ± 9.02*
MRSA ATTC 43300	500 ± 0.00	83.33 ± 36.08*	166.67 ± 72.16*
S. pneumoniae ATTC 25923	333.33 ± 144.33	104.17 ± 36.08	166.67 ± 72.16
VSE ATTC 19433	333.33 ± 144.33	83.33 ± 36.08*	52.08 ± 18.04*
VRE ATTC 51299	500 ± 0.00	166.67 ± 72.16*	104.17 ± 36.08*
A. baumannii ATTC 17978	333.33 ± 144.33	15.62 ± 0.00*	104.17 ± 36.08*
P. mirabilis ATTC 12459	250 ± 0.00	62.5 ± 0.00*	166.67 ± 72.16
K. pneumoniae ATTC 13883	333.33 ± 144.33	166.67 ± 72.16	166.67 ± 72.16
S. pyogenes ATTC 19615	166.67 ± 72.16	83.33 ± 36.08	62.5 ± 0.00
H. influenza e ATTC 29247	166.67 ± 72.16	83.33 ± 36.084	52.08 ± 18.04
S. epidermidis ATTC 12228	166.67 ± 72.16	20.83 ± 9.02*	26.04 ± 9.02*
E. aerogenes ATTC 29751	104.17 ± 36.08	15.62 ± 0.00*	26.04 ± 9.02*
C. freundii ATTC 8090	166.67 ± 72.16	83.33 ± 36.08	52.08 ± 18.04
E. cloacae ATTC 13047	166.67 ± 72.16	41.67 ± 18.04*	62.5 ± 0.00

MICs were determined using serial dilution method according to the procedures National Committee for Clinical Laboratory Standards.
* indicates significant difference from rosuvastatin group.

ISSN: 1476-0711