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Table 2 Effect of CTZ and CFS on intracellular killing of Salmonella Typhimurium NCTC 74 (assessed by isolating murine peritoneal macrophages from Balb/c mice and interacting them with Salmonella in presence of CFS and CTZ separately and in combination)

From: Effect of L. plantarum cell-free extract and co-trimoxazole against Salmonella Typhimurium: a possible adjunct therapy

Duration of intra-cellular incubation (min.)

CFU of S. Typhimurium

Mean Percentage Intracellular Killing {(No-Nt/N0)×100}

 

Untreated Macrophages

Treated Macrophages

Untreated Macrophages

Treated Macrophages

  

CTZ

CFS

CTZ

+

CFS

 

CTZ

CFS

CTZ

+ CFS

0 (N0)

80×107

-

-

-

 

-

-

-

30

71×107

63×107 *

69×107

60×107 *†

11.2

21.25

13.7

25

60

58×107

46×107 *

52×107 *

37×107 *†

27.5

42.5

35

53.75

90

45×107

29×107 *

41×107 *

6.1×107 *‡

43.75

63.75

48.75

92.3

  1. Co-trimoxazole-CTZ; Cell free supernatant from L. plantarum - CFS.