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Table 5 Effect of different extracts from Accacia salicina leaves on the mutagenicity induced by MMS in Salmonella thyphimurium TA104 and TA102 assay systems without S9

From: Antimutagenic and free radical scavenger effects of leaf extracts from Accacia salicina

  

TA104

TA102

Extracts

Doses

(μg/plate)

Nb revertants

% inhibition of mutagenesis

Nb revertants

% inhibition mutagenesis

Spontaneous

 

312 ± 8

-

234± 18

-

PC

 

2144 ± 23

-

1721± 24

-

Petroleum ether extract

25

1454 ± 95

37.66

1239 ± 73

32.41

 

10

1712 ± 45

23.58

1265 ± 42

30.66

 

5

2002 ± 43

7.75

1325 ± 56

2.63

Chloroform extract

25

965 ± 99

64.35

996 ± 68

48.75

 

10

1135 ± 64

55.07

1016 ± 82

47.41

 

5

1266 ± 59

47.92

1099 ± 47

41.82

Ethyl acetate extract

25

1328 ± 58

44.54

1109 ± 73

41.15

 

10

1475 ± 98

36.51

1195 ± 42

35.37

 

5

1813 ± 54

18.06

1235 ± 56

32.68

  1. Positive control (PC): S. typhimurium TA104/-S9, MMS (325 μg/plate); S. typhimurium TA102/-S9, MMS (130 μg/plate). MMS: Methylmethane sulfonate, 2-AA: 2-amino anthracene.