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Table 2 Effect of diclofenac on antibiotic susceptibility of COL, SH1000 and DcRS mutant derivatives

From: Alterations in the transcriptome and antibiotic susceptibility of Staphylococcus aureus grown in the presence of diclofenac

    

MICa (μg/ml)

  

Antibiotic

Strain

Control

Dc b (32 μg/ml)

FI/FD c

Dc (64 μg/ml)

FI/FD

Ciprofloxacin

SH1000

0.5

0.25

-2

0.125

-4

 

SC1-SC3d

0.5

0.25

-2

0.125

-4

 

COL

0.5

0.25

-2

0.25

-2

 

SC4-SC6d

0.5

0.5

0

0.25

-2

 

BB255

0.25

0.125

-2

0.125

-2

 

WGB8287

0.5

0.125

-4

0.125

-4

 

SA1199B

8

4

-2

4

-2

 

WBG9312

32

4

-8

4

-8

Norfloxacin

Alle

0.125

0.0625

-2

0.0625

-2

Ofloxacin

SA1199B

2

1

-2

0.5

-4

 

WBG9312

8

4

-2

4

-2

Oxacillin

SH1000

0.25

0.25

0

0.5

2

 

SC1-3

0.25

0.5

2

0.5

2

 

COL

>256

>256

ND

>256

ND

 

SC4-6

>256

>256

ND

>256

ND

 

BB255

0.25

0.25

0

0.25

0

 

WGB8287

32

64

2

128

4

 

SA1199B

0.13

0.25

2

0.5

4

 

WBG9312

2

8

4

16

8

  1. a Minimum inhibitory concentration (MIC).
  2. b Diclofenac (Dc).
  3. c Fold increase (FI) or fold decrease (FD) in MIC and in the presence of Dcl.
  4. d DcRS mutant derivative isolates of SH1000 (SC1 through SC3) all had the same MICs; those of COL (SC4 through SC6) also all had the same MICs.
  5. e All (all strains in the study expressed the same MIC: SH1000, COL, SC1-SC6, BB255, WGB8287, SA1199B, and WBG9312).
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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