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Table 1 Minimum inhibitory and minimum bactericidal concentrations in μg/ml of thymoquinone and tetracycline and their combination

From: Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens

  MIC TQ MBC TQ MIC TET MBC TET aMIC TET
+ 1/2MIC TQ
MBC TET
+ 1/2MIC TQ
References strains       
Bacillus cereus ATCC 14579 8 8 2 8 0.5 (4) 4 (2)
Escherichia coli ATCC 35218 512 512 4 16 2 (2) 64 (4)
Enterococcus faecalis ATCC 29212 32 128 256 512 128 (2) 64 (8)
Salmonella enterica serovar Typhimurium ATCC 1408 256 512 128 256 32 (4) 128 (2)
Staphylococcus aureus ATCC 25923 8 16 4 8 0.5 (8) 4 (2)
Staphylococcus epidermidis CIP 106510 8 8 8 16 4 (2) 64 (4)
Listeria monocytogenes ATCC 19115 32 128 1 4 1 (NC) 4 (NC)
Micrococcus luteus NCIMB 8166 8 64 32 64 8 (4) 16 (4)
Pseudomonas aeruginosa ATCC 27853 >512 >512 64 128 32 (2) 256 (2)
Vibrio alginolyticus ATCC 33787 512 512 256 512 128 (2) 256 (2)
Vibrio paraheamolyticus ATCC 17802 32 64 4 32 0.5 (8) 8 (4)
Oral strains       
E. faecalis B281 256 256 64 256 64 (NC) 128 (2)
Gemella haemolysans B234 128 128 512 256 256 (2) 256 (NC)
Staphylococcus aureus B73 256 256 64 128 16 (4) 16 (8)
Staphylococcus aureus B285 8 32 4 4 4 (NC) 8 (2)
Staphylococcus aureus B291 256 256 128 128 32 (4) 64 (2)
Staphylococcus aureus B289 16 16 4 4 <0.5 (>8) 2 (2)
Staphylococcus aureus B456 16 32 32 128 4 (8) 16 (8)
Staphylococcus aureus B244 16 32 32 32 4 (8) 8 (4)
Staphylococcus aureus B364 256 256 4 8 8 (2) 8 (NC)
Staphylococcus aureus B398 8 16 16 16 4 (4) 4 (4)
Streptococcus anginosus B486 64 64 128 256 64 (2) 128 (2)
Streptococcus constellatus B629 32 64 <0,5 4 <0.5 (NC) 4 (NC)
Streptococcus mitis B627 128 256 128 256 32 (4) 128 (2)
Streptococcus mutans B509 16 16 <0,5 8 <0.5 (NC) 4 (2)
Streptococcus oralis B634 32 64 128 128 32 (4) 64 (2)
Streptococcus salivarius B468 16 32 4 16 2 (2) 8 (2)
  1. aFold reductions are given in parentheses; NC, no change; TQ, thymoquinone; TET, Tetracycline
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