Antimicrobial activity and mechanism of action of Nu-3, a protonated modified nucleotide

Table 3 Comparative study of Nu-3 against P. aeruginosa cvcc 5668 and S. aureus cvcc 2248 with Ciprofloxacin in mouse suture wound model.

Treatments	Mean bacterial counts ± SD (Log10CFU/wound)^a
	*P. aeruginosa cvcc5668*	*S. aureus cvcc2248*
Initial innoculation	4.93 ± 0.33	4.79 ± 0.31
Untreated	7.52 ± 0.57	7.64 ± 0.58
Glycerin solution	7.34 ± 0.27	7.47 ± 0.34
5% Nu-3 in saline	5.62 ± 0.61**	5.23 ± 0.5**
5% Nu-3 glycerin solution	5.07 ± 0.53**	4.51 ± 0.55**
Ciprofloxacin hydrochloride ointment	4.82 ± 0.58**	5.63 ± 0.31**

a, n = 6; ** P < 0.001 in comparison with the untreated control. 5% Nu-3 is equivalent to 50 mg Nu-3 in 1 ml 60% glycerin solutions and 1% Nu-3 is 10 mg Nu-3 in 1 ml 60% glycerin solutions.

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