Skip to main content

Table 3 Comparative study of Nu-3 against P. aeruginosa cvcc 5668 and S. aureus cvcc 2248 with Ciprofloxacin in mouse suture wound model.

From: Antimicrobial activity and mechanism of action of Nu-3, a protonated modified nucleotide

Treatments Mean bacterial counts ± SD (Log10CFU/wound)a
  P. aeruginosa cvcc5668 S. aureus cvcc2248
Initial innoculation 4.93 ± 0.33 4.79 ± 0.31
Untreated 7.52 ± 0.57 7.64 ± 0.58
Glycerin solution 7.34 ± 0.27 7.47 ± 0.34
5% Nu-3 in saline 5.62 ± 0.61** 5.23 ± 0.5**
5% Nu-3 glycerin solution 5.07 ± 0.53** 4.51 ± 0.55**
Ciprofloxacin hydrochloride ointment 4.82 ± 0.58** 5.63 ± 0.31**
  1. a, n = 6; ** P < 0.001 in comparison with the untreated control. 5% Nu-3 is equivalent to 50 mg Nu-3 in 1 ml 60% glycerin solutions and 1% Nu-3 is 10 mg Nu-3 in 1 ml 60% glycerin solutions.