Antimicrobial activity and mechanism of action of Nu-3, a protonated modified nucleotide

Table 2 Dose-response of Glycerin-Nu-3 solution in inhibition of P. aeruginosa cvcc 5668 and S. aureus cvcc 2248 growth in mouse suture-wound model.

	Mean bacterial counts ± SD (Log10CFU/wound)^a
Treatments	*P. aeruginosa cvcc5668*	*S. aureus cvcc2248*
Initial innoculation	4.66 ± 0.12	4.88 ± 0.56
Untreated	7.24 ± 0.30	7.18 ± 0.57
Glycerin solution	6.86 ± 0.19	7.04 ± 0.48
1% Nu-3 in Glycerin	6.73 ± 0.27*	6.34 ± 0.32*
5% Nu-3 in Glycerin	5.76 ± 0.42**	4.95 ± 0.21**

a, n = 6; * P < 0.01; **P < 0.001 in comparison with the untreated control. 5% Nu-3 is equivalent to 50 mg Nu-3 in 1 ml 60% glycerin solutions and 1% Nu-3 is 10 mg Nu-3 in 1 ml 60% glycerin solutions.

ISSN: 1476-0711