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Table 2 Dose-response of Glycerin-Nu-3 solution in inhibition of P. aeruginosa cvcc 5668 and S. aureus cvcc 2248 growth in mouse suture-wound model.

From: Antimicrobial activity and mechanism of action of Nu-3, a protonated modified nucleotide

  Mean bacterial counts ± SD (Log10CFU/wound)a
Treatments P. aeruginosa cvcc5668 S. aureus cvcc2248
Initial innoculation 4.66 ± 0.12 4.88 ± 0.56
Untreated 7.24 ± 0.30 7.18 ± 0.57
Glycerin solution 6.86 ± 0.19 7.04 ± 0.48
1% Nu-3 in Glycerin 6.73 ± 0.27* 6.34 ± 0.32*
5% Nu-3 in Glycerin 5.76 ± 0.42** 4.95 ± 0.21**
  1. a, n = 6; * P < 0.01; **P < 0.001 in comparison with the untreated control. 5% Nu-3 is equivalent to 50 mg Nu-3 in 1 ml 60% glycerin solutions and 1% Nu-3 is 10 mg Nu-3 in 1 ml 60% glycerin solutions.