Table 5 MIC results, Drug susceptibility profile, efflux pump expression and VP treatment, in 4 fully susceptible isolates
No. | BDQ | INH | RIF | STR | EMB | KAN | OFX | CAP | MIC BDQ | BDQ + VP | MIC fold change | Genes overexpressed under BDQ | Genes down-regulated under VP + BDQ stress |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PII-6 | S | S | S | S | S | S | S | S | 0.125 | 0.007 | 17.8 | Rv0676c | Rv0676c - Rv1410c |
PII-8 | S | S | S | S | S | S | S | S | 0.125 | 0.0039 | 32 | * | * |
PII-10 | R | S | S | S | S | S | S | S | 1 | 0.06 | 16 | * | Rv3065- Rv0676c - Rv1258c - Rv1410c - Rv1634- Rv1819- Rv2459- Rv2846 |
PII-11 | R | S | S | S | S | S | S | S | 0.5 | 0.0625 | 8 | Rv3065 | Rv0676c - Rv1258c - Rv1410c - Rv1634- Rv1819- Rv2459- Rv2846 |