Table 4 MIC results, Drug susceptibility profile, efflux pump expression and VP treatment, in 15 MDR and XDR isolates
No. | BDQ | INH | RIF | STR | EMB | KAN | OFX | CAP | MIC BDQ | MIC BDQ + VP | MIC reduction fold change | Genes overexpressed under BDQ | Genes down regulated under VP + BDQ stress |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PII-20 (MDR) | R | R | R | R | R | S | S | S | 8 | 0.06 | 133 | Rv3065 | * |
PII-21 (MDR) | R | R | R | R | R | S | S | R | 0.5 | 0.5 | * | Rv1410c | Rv1410c- Rv1819 |
PII-22 (MDR) | R | R | R | R | R | S | S | R | 1 | 0.007 | 142 | Rv0676c | Rv0676c - Rv1819- Rv2459- Rv1634 |
PII-23 (MDR) | R | R | R | R | R | R | S | R | 4 | 0.0625 | 64 | * | * |
PII-24 (MDR) | R | R | R | R | R | R | S | R | 0.5 | 0.0156 | 32 | * | Rv1410c |
PII-26 (XDR) | R | R | R | S | R | S | R | R | 8 | 8 | * | Rv0676c -Rv1410c | Rv1410c - Rv2459 |
PII-28 (MDR) | R | R | R | S | R | S | S | R | 8 | 0.06 | 133 | Rv0676c - Rv2846- Rv1634- Rv3065- Rv1819 | Rv3065- Rv2846 |
PII-30 (XDR) | R | R | R | R | R | R | R | R | 8 | 0.06 | 133 | * | * |
PII-31 (XDR) | R | R | R | R | R | S | R | R | 2 | 0.0156 | 128 | Rv2459- Rv3065- Rv1410c - Rv1634- Rv0676c | Rv0676c - Rv1258c - Rv1410c - Rv1819 |
PII-32 (MDR) | R | R | R | R | R | S | S | S | 4 | 0.125 | 32 | * | * |
PII-33 (XDR) | R | R | R | R | R | R | R | R | 0.5 | 0.5 | * | Rv0676c - Rv1258c - Rv2846 | Rv1258c - Rv2846 |
PII-35 (XDR) | R | R | R | R | R | S | R | S | 8 | 0.06 | 133 | Â | Rv0676c - Rv1258c- Rv1410c - Rv1634 |
PII-3 (XDR) | R | R | R | R | R | R | R | R | 1 | 0.125 | 8 | Rv0676c - Rv2459- Rv1819 | Rv0676c - Rv1634 |
PII-9 (XDR) | R | R | R | R | R | R | R | R | 8 | 0.06 | 133 | * | * |
PII-15 (XDR) | R | R | R | R | R | R | R | R | 8 | 0.125 | 64 | Rv1258c | Rv1258c |