Table 1 Clinical characteristics of patients with KPC-2-NDM-1-CR-hvKP
Variables/patients | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 |
|---|---|---|---|---|---|
Strain | JNKPN23 | JNKPN24 | JNKPN26 | JNKPN29 | JNKPN31 |
Clinical characteristics | |||||
 Age | 70 | 70 | 44 | 56 | 69 |
 Gender | Female | Female | Female | Female | Female |
 City | JINAN | JINAN | JINAN | JINAN | JINAN |
 Ward | ICU | ICU | ICU | ICU | ICU |
 Underlying conditions | Right oophorectomy, myocardial ischemia, chronic ischemic heart disease, respiratory failure | Hypertension, diabetes, dyslipidemia | Hepatic cyst, splenic cyst | Esophageal squamous cell carcinoma | Hypertension, diabetes, UTI |
Invasive procedures | |||||
 Mechanical ventilation | Yes | Yes | Yes | Yes | Yes |
 Drainage catheters | Yes | Yes | Yes | Yes | Yes |
 Surgery | Yes | Yes | Yes | Yes | Yes |
 Date of specimen collection | 2019/2/5 | 2019/2/15 | 2019/2/28 | 2019/3/6 | 2019/3/15 |
 Infection type | Severe pneumonia, sepsis | Severe pneumonia, sepsis | Severe pneumonia | Severe pneumonia | Severe pneumonia |
 Prior antibiotic usage within 30 days | Yes | Yes | Yes | Yes | Yes |
 Empirical antimicrobial usage | CSL + POL + TZP + TGC | TZP + TGC | CSL + TZP + CIP + LZD + POL + ETS | CXM + CSL + ETS + LZD + MIN | ETS + TZP + LEV |
Clinical presentations | |||||
 Temperature (max °C) | 39.2 °C | 38.6 °C | 39.5 °C | 39.1 °C | 38.2 °C |
 WBC (×109/L) | 27.83 | 29.49 | 28.73 | 20.93 | 16.04 |
 Therapeutic antimicrobial usage | TOB + IPM + TGC | TZP + TGC + POL | LZD + POL + MEM + LEV + TZP + ETS | LZD + MIN | LEV |
Clinical outcomes | |||||
 Days of mechanical ventilation | 6 | 12 | 51 | 10 | 7 |
 Duration of ICU stay (days) | 6 | 12 | 56 | 29 | 30 |
 Outcome | Death | Death | Survived | Death | Survived |