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Table 3 Characteristics of patients with oral sequential treatment

From: Carbapenem alternatives for treatment of bloodstream infections due to AmpC producing enterobacterales

 

Non-OST

(n = 41)

OST

(n = 36)

P

Age, mean years (IQR)

71 (58–82)

75 (66–80)

0.617

Male, n (%)

24 (59)

33 (92)

0.001

Comorbidities, n (%)

   

 - ischemic heart disease

 - dementia

 - COPD

 - diabetes mellitus

 - chronic kidney failure

 - solid tumour

3 (7)

5 (12)

6 (15)

4 (10)

5 (12)

11 (27)

8 (22)

3 (8)

3 (8)

8 (22)

4 (11)

12 (33)

0.101

0.717

0.490

0.208

0.999

0.621

Charlson index ≥ 3, n (%)

21 (51)

11 (31)

0.104

Source of infection, n (%)

   

 - urinary

 - catheter

 - respiratory

 - abdominal

 - surgical wound

 - cutaneous

 - unknown

12 (29)

7 (17)

2 (5)

6 (15)

1 (2)

0

3 (7)

14 (39)

4 (11)

0

2 (6)

3 (8)

1 (3)

1 (3)

0.470

0.528

0.496

0.271

0.335

0.468

0.618

Sepsis, n (%)

23 (56)

11 (31)

0.038

ICU admission, n (%)

11 (27)

5 (14)

0.260

P-T/CEF, n (%)

23 (56)

32 (89)

0.002

Adverse events, n (%)

2 (5)

0

0.496

In-hospital stay (IQR)

18 (13–38)

14 (7–22)

0.005

Recurrence, n (%)

2 (5)

1 (3)

0.999

  1. Note; CEF, cefepime; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; IQR, Interquartile Range; P-T, piperacillin-tazobatam; OST, oral sequential therapy