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Table 1 Antibiotic susceptibility of three XDR P. aeruginosa collected from the patient during the clinical course

From: Compassionate use of a novel β-lactam enhancer-based investigational antibiotic cefepime/zidebactam (WCK 5222) for the treatment of extensively-drug-resistant NDM-expressing Pseudomonas aeruginosa infection in an intra-abdominal infection-induced sepsis patient: a case report

Antibiotics

 

MICs (mg/L)

 

Endotracheal secretion samples

 

Abdominal tissue sample

 

hospital day 13

hospital day 17

 

hospital day

27

 

ISOLATE 1

ISOLATE 2

 

ISOLATE 3

Cefepime

 

> 64

> 64

 

> 64

Cefepime/zidebactam

 

16

16

 

16

Ceftazidime

 

> 64

> 64

 

> 64

Ceftazidime/avibactam

 

> 64

> 64

 

> 64

Imipenem

 

> 64

> 64

 

> 64

Imipenem/relebactam

 

> 64

> 64

 

> 64

Ceftolozane/tazobactam

 

> 64

> 64

 

> 64

Piperacillin/tazobactam

 

> 64

> 64

 

> 64

Meropenem

 

> 64

> 64

 

> 64

Amikacin

 

> 64

> 64

 

> 64

Levofloxacin

 

> 64

> 64

 

> 64

Fosfomycin

 

> 256

> 256

 

> 256

Colistin

 

0.25

0.25

 

0.25

Polymyxin B

 

0.12

0.25

 

0.25

Imipenem + EDTA

 

16

16

 

16

Ceftazidime/avibactam + EDTA

 

16

16

 

16

  1. Cefepime/zidebactam MICs were determined in 1:1 ratio;
  2. For all the β-lactamase inhibitor based combination, inhibitor was at fixed 4 mg/L
  3. EDTA: Ethylene diamine tetraacetic acid at fixed 200 mg/L
  4. For fosfomycin, agar MIC method was employed by supplementing the medium with glucose-6-phosphate at 25 mg/L