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Table 1 MICs (mg/L) of antimicrobial agents against strains in this study

From: Resistance to aztreonam-avibactam due to a mutation of SHV-12 in Enterobacter

Antimicrobial agents

020047

020047R

DH5α::SHV-12

DH5α::SHV-12R

CEPa

> 1024

> 1024

1024

16

FUR

1024

1024

128

4

CTX

> 1024

1024

32

0.06

PIP-TAZ

> 512/4

> 512/4

256/4

2/4

CAZ

> 1024

> 1024

512

4

CAZ-AVI

> 512/4

> 512/4

0.25/4

0.25/4

IMP

16

16

0.12

0.12

ATM

2048

256

512

32

ATM-AVI

1/4

16/4

0.5/4

4/4

ATM-CLA

32/16

32/16

1/0.5

2/1

ATM-TAZ

> 512/4

256/4

128/4

2/4

ATM-SUL

256/128

256/128

32/16

8/4

  1. CEP, cephalothin; FUR, cefuroxime; CTX, cefotaxime; PIP-TAZ, piperacillin-tazobactam; CAZ, ceftazidime; CAZ-AVI, ceftazidime-avibactam; IMP, imipenem; ATM, aztreonam; ATM-AVI, aztreonam-avibactam; ATM-CLA, aztreonam-clavulanic acid; ATM-TAZ, aztreonam-tazobactam; ATM-SUL, aztreonam-sulbactam
  2. Those reached the breakpoints to define resistance are highlighted in bold. The breakpoint of ATM-AVI, ATM-CLA, ATM-TAZ, and ATM-SUL to define resistance were according to that of ATM.
  3. aUsing breakpoints of cefazolin for infections other than uncomplicated urinary tract infection [11]