Table 1 Participants with central venous catheter infection who underwent antibiotic lock with daptomycin
Case 1 | Case 2 | Case 3 | |
|---|---|---|---|
Age (years) | 2 | 15 | 2 |
Underlying disease | Hemophilia A | Hemophilia A | VII factor deficiency |
Type of catheter | Port-A-Cath | Port-A-Cath | Port-A-Cath |
Microorganism | S. epidermidis | S. oralis | S. condimenti |
Systemic therapy before starting daptomycin | Vancomycin (40 mg/kg/day) | Amoxicillin—Clavulanic acid (100 mg/kg/day) | Vancomycin (40 mg/kg/day) and Rifampicin (20 mg/kg/day) |
Previous antibiotic lock | Vancomycin | Vancomycin | Vancomycin |
Duration with previous antibiotic lock (days) | 3 | 2 | 7 |
Indication for antibiotic lock with daptomycin | Persistent positives blood cultures | Persistent positives blood cultures and fever | Persistent positives blood cultures |
Systemic therapy associated with antibiotic lock | Vancomycin (40 mg/kg/day) | Amoxicillin—Clavulanic acid (100 mg/kg/day) | Daptomycin (10 mg/kg/day) |
Blood culture since starting daptomycin sealing (days) | 2 | 1 | 5 |
Duration of antibiotic lock with daptomycin (days) | 16 | 6 | 15 |
Catheter removal | No | No | No |
Relapse | No | No | No |
Total hospital stay (days) | 9 | 12 | 71* |
Hospital stay since the start of the antibiotic lock with daptomycin (days) | 7 | 3 | 60* |
Adverse effects | No | No | No |