Fig. 3From: Evolution of carbapenem resistance in klebsiella pneumoniae and escherichia coli carrying blaNDM−1 gene: imipenem exposure results in sustained resistance memory of strains in vitroEffect of imipenem on the growth of all three strains. Firstly, the same strain was exposed to imipenem of 0.125 µg/mL (MIC ˂1 µg/mL), and then exposed to imipenem at grade increasing (0.25 µg/mL, 0.5 µg/mL, 1 µg/mL, 2 µg/mL, 4 µg/mL, 8 µg/mL, and 12 µg/mL), decreasing (12 µg/mL to 8 µg/mL, 8 µg/mL to 4 µg/mL, and 4 µg/mL to 0 µg/mL), and canceling (12 µg/mL to 0 µg/mL, 8 µg/mL to 0 µg/mL, and 4 µg/mL to 0 µg/mL) doses, respectively. Bacterial growth curve was drawn with GraphPad 7.0 softwareBack to article page