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Fig. 3 | Annals of Clinical Microbiology and Antimicrobials

Fig. 3

From: Evolution of carbapenem resistance in klebsiella pneumoniae and escherichia coli carrying blaNDM−1 gene: imipenem exposure results in sustained resistance memory of strains in vitro

Fig. 3

Effect of imipenem on the growth of all three strains. Firstly, the same strain was exposed to imipenem of 0.125 µg/mL (MIC ˂1 µg/mL), and then exposed to imipenem at grade increasing (0.25 µg/mL, 0.5 µg/mL, 1 µg/mL, 2 µg/mL, 4 µg/mL, 8 µg/mL, and 12 µg/mL), decreasing (12 µg/mL to 8 µg/mL, 8 µg/mL to 4 µg/mL, and 4 µg/mL to 0 µg/mL), and canceling (12 µg/mL to 0 µg/mL, 8 µg/mL to 0 µg/mL, and 4 µg/mL to 0 µg/mL) doses, respectively. Bacterial growth curve was drawn with GraphPad 7.0 software

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