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Table 2 Estimation of different parameters in the pharmacodynamic modeling of the anti-biofilm potential of a single antibiotic against P. aeruginosa isolates

From: Mathematical pharmacodynamic modeling for antimicrobial assessment of ceftazidime/colistin versus gentamicin/meropenem combinations against carbapenem-resistant Pseudomonas aeruginosa biofilm

Isolate

CRPA-45

CRPA-47

Antimicrobial agent

EC50

AUC

Hill factor

EC50

AUC

Hill factor

Ceftazidime

2163.5

12675.2

0.78

350

2205.6

0.92

Colistin

22.4

120.4

0.84

15.2

70.4

0.84

Gentamicin

160.3

1256.5

0.87

91.5

670.8

0.97

Meropenem

202.5

1508.7

0.89

84.4

643.3

0.93

  1. EC50 Effective concentration of the antibiotic that causes 50% of the maximum antibacterial effect, AUC area under the curve
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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