Mathematical pharmacodynamic modeling for antimicrobial assessment of ceftazidime/colistin versus gentamicin/meropenem combinations against carbapenem-resistant Pseudomonas aeruginosa biofilm

Table 1 Antimicrobial susceptibility profiles against planktonic cells and biofilms of P. aeruginosa clinical isolates

Isolate	Antimicrobial agent	MIC (µg/ml)	Susceptibility	MBC (µg/ml)	MBIC (µg/ml)	MBBC (µg/ml)
CRPA-45	Ceftazidime	32	R	64	256	512
	Colistin	4	R	8	16	32
	Gentamicin	16	R	32	64	256
	Meropenem	16	R	32	64	512
CRPA-47	Ceftazidime	16	I	32	128	256
	Colistin	2	S	4	8	16
	Gentamicin	8	I	16	32	128
	Meropenem	8	R	16	32	256

MIC minimum inhibitory concentration, R resistant, I intermediate, S sensitive, MBC minimum bactericidal concentration, MBIC minimum biofilm inhibitory concentration, MBBC minimum biofilm bactericidal concentration

ISSN: 1476-0711