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Table 1 Summary of the included studies

From: Is hybrid therapy more efficient in the eradication of Helicobacter pylori infection? A systematic review and meta-analysis

Publication Year

First Author

Country

HT

Controls

Total Enrolled

Patient Characteristics

Infection diagnosis

Resistance rates

Treatment duration (days)

Eradication

Eradication rates (ITT)%

2020

Antonio Mestrovic

Croatia

71

69 (CT)

140

Dyspeptic symptoms

SAT, RUT, UBT, HA

CAM > 20%, MET 10.2%

14

SAT

83.1

2015

Jun Heo

Korea

241

209 (CT)

422

Dyspeptic symptoms

RUT, UBT or HA

CAM ≥ 20%, MET ≥ 30%

10

UBT

78.8

2015

Jae Jin Hwang

Korea

144

140 (ST)

284

Gastritis and/or Peptic Ulcer Disease

UBT, HA, RUT

CAM 37.3%, MET 35.8%

14

UBT

79.2

2014

Vincenzo De Francesco

Italy

110

330 (ST or CT)

440

Dyspeptic symptoms

RUT and HA

N/A

10 (SQ), 14 (HT, CT)

UBT

82.7

2013

Hossein Sardarian

Iran

210

210 (ST)

420

Gastric or Duodenal Erosions

HA and/or RUT

CAM 30%, MET 73.4%, AMOX 6.3%, DR* 21.2%

14 (HT), 10 (ST)

UBT

89.5

2014

Dong Hyun Oh

Korea

90

94 (ST)

184

Dyspeptic symptoms

RUT or HA

CAM 23.7% AMOX 14.9%

14

UBT

81.1

2013

Javier Molina-Infante

Italy + Spain

171

172 (CT)

343

Dyspeptic symptoms

UBT, RUT, HA or Ct

CAM 23.5%, MET 33%, DR 8.8%**

14

UBT

92

2015

Antonio Cuadrado-Lavín

Spain

120

120 (CT)

300

Dyspeptic symptoms

UBT, HA or RUT

CAM ~ 14%

10

UBT

90.8

2018

Ayşe Kefeli

Turkey

170

170 (ST)

340

Gastritis

HA

CAM 40.2%, MET 45.5%

14

UBT

86.5

2017

Sahoo Ashokkumar

South India

60

60 (ST)

120

Gastritis and/or Peptic Ulcer Disease

HA

CAM 33%, MET 78%

14 (HT), 10 (ST)

HA or RUT

88.3

  1. RCT randomized clinical trial, HT Hybrid therapy, CT Concomitant therapy, SQ Sequential therapy, SAT stool antigen test, RUT rapid urease test, UBT urea breath test, HA histological assessment, Ct culture, CAM Clarithromycin, MET Metronidazol, AMOX Amoxicillin, DR double resistance, ITT Intention-to-treat
  2. **prevalence of resistance rates in the settings where the trial was conducted
  3. *(clarithromycin + metronidazole)