Influence of borderline cefepime MIC on the outcome of cefepime-susceptible Pseudomonas aeruginosa bacteremia treated with a maximal cefepime dose: a hospital-based retrospective study

Table 3 Multivariate analyses of risk factors for 30-day crude mortality of cefepime-susceptible Pseudomonas aeruginosa bacteremia treated with cefepime

Variables	p	OR	95% CI
MIC ≥4 mg/L	0.039	5.111	1.090–23.974
Use of maximum cefepime dose	0.031	0.271	0.082–0.889
Age, year	0.023	1.065	1.011–1.122
Lower respiratory tract infections	0.056	4.008	0.967–16.621
APACHE II score	0.824	0.986	0.869–1.119
Intensive care unit stay^a	0.146	2.945	0.687–12.619
Severe sepsis or septic shock^a	0.210	2.609	0.582–11.706
Time interval between admission and occurrence of bacteremia	0.861	1.002	0.983–1.021
Treatment duration	0.063	0.923	0.848–1.004

All variables with p < 0.1 in univariate analysis were included in a multivariate regression model using the backward stepwise method
OR odds ratio, CI confidence interval, MIC minimal inhibitory concentration
^aThe factors of intensive care unit stay and severe sepsis or septic shock had strongly correlation (correlation coefficient 0.9), however, single factor with either intensive care unit stay or severe sepsis and septic shock were still remained insignificantly in the multivariate analyses model (factor with intensive care unit only: adjusted OR 3.127, 95% CI 0.746–13.111, p = 0.119; factor with severe sepsis or septic shock only: adjusted OR 2.813, 95% CI 0.647–12.226, p = 0.168)

ISSN: 1476-0711