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Table 1 PCR-results with a total of 380 tissue samples obtained from non-infected (control) and N. caninum-infected calves without and with ponazuril therapy (1T = medication for one day; 6T = medication for 6 consecutive days). Bold numbers indicate the number of positive samples per total number of samples analyzed; – means that no sample was PCR-positive. Infected animals without therapy were euthanized on day 45 p.i. (nos. 1–3) and 90 p.i. (nos. 4–6)

From: An explorative study to assess the efficacy of Toltrazuril-sulfone (Ponazuril) in calves experimentally infected with Neospora caninum

 

without infection

infection, without therapy

infection, with therapy

() = number of calves tested

without therapy (2)

with therapy_6T (2)

no.1 (1)

no.2 (1)

no.3 (1)

no.4 (1)

no.5 (1)

no.6 (1)

with therapy_1T (5)

with therapy_6T (4)

brain

- / 20

- / 20

- / 10

2 / 10

- / 10

- / 10

1 / 10

- / 10

- /50

- /40

heart

- / 6

- / 6

- / 3

- / 3

1 / 3

- / 3

- / 3

- / 3

- /15

- /12

muscles*

- / 6

- / 6

- / 3

1 / 3

- / 3

- / 3

1 / 3

- / 3

- /15

- /12

liver

- / 8

- / 8

- / 4

- / 4

- / 4

- / 4

- / 4

- / 4

- /20

- /16

  1. *muscles: per animal, one sample from the M. masseter, one from the diaphragma and one from the tongue, respectively.